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3.3.3 GPX4-independent ferroptosis pathways In addition to GPX4-dependent antioxidant system in ferroptosis, so far there are alternative identified ferroptosis pathways, including ferroptosis suppressor protein 1(FSP1)/coenzyme Q10 (Co Q10) (Mao et al., 2021), GTP cyclohydrolase 1 (GCH1)/ tetrahydrobiopterin (BH4) (Kraft et al., 2020), 7-dehydrocholesterol (7-DHC) (Cao et al., 2025), and phospholipid modifying enzymes MBOAT1/2 (Liang et al., 2023), which act as suppressing ferroptosis wither by scavenging radicals for lipid peroxidation or modulating genes regulating lipid peroxidation
Genetic instruments were derived from cis-eQTLs for GLP-1R, and analyses were conducted using large-scale GWAS datasets
When your appetite is low, chewing through a chicken breast can feel like a monumental task
By its very nature, alcohol can disrupt gut motility and even alter the balance of bacteria in the digestive system
Lifestyle approaches including protein and fibre intake, regular physical activity, healthy weight maintenance, and quality sleep may support natural GLP-1 function and overall metabolic health
Diabetes care 34 , 20412047, doi:10.2337/dc11-0291 (2011)
