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doi: 10.5195/cajgh.2016.241 113 KulkarniSSMishraSPatilSBNambiarJMathA

Standard of Care) study for alogliptin (58, 62), the Savor-TIMI-53 study (Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes MellitusThrombolysis in Myocardial Infarction 53) for saxagliptin (60, 63), the TECOS study (Trial Evaluating Cardiovascular Outcomes With Sitagliptin) for sitagliptin (59, 64) and the CARMELINA study (Cardiovascular safety and Clinical Outcome with Linagliptin) for linagliptin (61, 65)

The peak intensities were further assessed by a filtering algorithm in the metabolomics BinBase database using protocols previously described by Fiehn 37 , and data were normalized by a normalization factor (mTIC), which was the sum of all peak heights for all identified metabolites (of only the known compounds)

Prebiotics are a form of fiber that feeds gut bacteria, allowing them to flourish and carry out critical metabolic activities

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Saxagliptin has significant drug interactions because it is extensively metabolized by CYP 3A4/5 and to a lesser extent CYP 2C8 in the liver (Dave, 2011)