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GLP-1 side effects GLP-1 medications have a different side effect profile, heavily weighted toward gastrointestinal symptoms: Nausea (the most common, affecting 40-50% initially, but typically improving over weeks) Bloating and abdominal discomfort The key difference is trajectory

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For many people, gastrointestinal side effects like heartburn are most prominent during the first few weeks of treatment or when the dosage is increased

J Biol Chem , 280:4052440533

Berberine has poor bioavailability, with only 5 percent absorbed from the intestinal tract