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Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig

Breaking the fast with protein rather than carbohydrates maintains stable energy and supports muscle preservation

Protein aggregates can trigger immune reactions at the injection site or systemically

Taken together, the prevention of oxidative stress and inflammation is a key mechanism for the renoprotective effects of GLP-1RAs

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