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To truly maximize the benefits, its crucial to understand the common pitfalls that sabotage glutathiones action
That said, interest and approval arent the same thing, and its worth understanding where the science currently stands
Thus, the regulatory effect of natural small molecule compounds on ferroptosis, especially on the treatment of kidney diseases, has attracted wide attention
The primary pathways for clearing L-OOHs in ferroptosis are the cystine/glutamate antiporter system-glutathione-glutathione peroxidase 4 axis (System Xc-/GSH/GPX4 axis), the ferroptosis suppressor protein 1-coenzyme Q10-nicotinamide adenine dinucleotide phosphate axis (FSP1/CoQ10/NADPH axis), and the GTP cyclohydrolase 1-tetrahydrobiopterin-dihydrofolate reductase axis (GCH1/BH4/DHFR axis) (Figure 1C)
doi: 10.1016/j.jacbts.2018.09.004 44 DunganKDeSantisA
1h and ESM Fig
