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Inhibition of NAD + consumption The excessive activation of PARPs or CD38 causes a NAD + consumption up to the extent that leads to ATP decline, energy loss and cell death

In a stacked format, the working idea is broader

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In neurons, Grx has a protective effect on redox-sensitive enzymes and ion channels, meaning that its dysfunction is implicated in several neurodegenerative disorders involving protein misfolding and redox signaling dysregulation (Ogata et al., 2021)

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