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Since their introduction, GLP-1 medications have rapidly gained popularity for their effectiveness in helping people manage diabetes and obesity
The AAPS Journal, 16 (4), 658673
So while it is a known side effect, its still considered relatively uncommon
Topical anesthetics for pain and warm tub baths (sitz baths) for 10-20 minutes several times a day (especially after bowel movements) are soothing and promote relaxation of the anal muscles, which may help the healing process.Other medications (such as nitroglycerin, nifedipine, or diltiazem) may be prescribed that allow relaxation of the anal sphincter muscles
Some findings suggest that Ozempic may have protective effects on the brain, as previously mentioned
Additionally, GCGR activation may indirectly influence fibrogenesis by modulating the hepatic metabolic milieu, reducing lipotoxicity and oxidative stress that serve as upstream triggers for fibrotic pathways (39, 47)
