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Future studies should clarify these context-specific mechanisms to enable safe and precise application of SIRT1-targeted therapies in metabolic liver disease

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There is also a natural decrease in glutathione levels with age

In normal physiology it participates in hepatic fat processing and methylation reactions, and it contributes to the livers handling of triglycerides and cholesterol

Roos DH, Seeger RL, Puntel RL, Barbosa NV (2012b) Role of calcium and mitochondria in MeHg-mediated cytotoxicity