Importantly, these effects were sustained for up to 3 years, supporting the use of once weekly semaglutide for the long-term management of type 2 diabetes, Karasik added
So this is why when people are on larger doses, they can stop eating altogether
Studies also show that results can last for two years or more when treatment continues
The insula, for example, is reliably activated during threat anticipation (Sambuco, Costa, et al., 2020b, 2020a) but less so during free viewing of emotional images, where inferior frontal gyrus (IFG) activation near opercular regions may be the primary driver (Sambuco, Bradley, et al., 2020), and spatial smoothing could misattribute these effects to the adjacent insula
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it cannot settle causation