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Lashen, H

This means oral formulations require much higher nominal doses to achieve similar blood levels

Brennan BP, Jensen JE, Hudson JI, et al

The signaling pathway works through interleukin-6 (IL-6) induction

1 ESSENCE Clinical Trial This approval is supported by results from the phase 3 ESSENCE trial (NCT04822181) that evaluated the effect of once-weekly subcutaneous semaglutide 2.4 mg in adults with non-cirrhotic MASH and stage 2 or 3 liver fibrosis

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