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To qualify under the labeled indication: Adult (18 or older) Diagnosed with moderate to severe obstructive sleep apnea (AHI of 15 or higher on a polysomnography or home sleep test) Body mass index of 30 or higher (obesity) Plus the standard tirzepatide cautions: no personal or family history of medullary thyroid carcinoma or MEN 2, no severe gastroparesis, etc
Liraglutide (Saxenda/Nevolat) is injected once a day
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Be alert to symptoms that may indicate thyroid dysfunction , such as: Worsening fatigue, cold intolerance, or constipation (suggesting under-replacement) Palpitations, anxiety, tremor, or heat intolerance (suggesting over-replacement) A lump or swelling in the neck, hoarseness, or difficulty swallowing (which should prompt urgent evaluation according to NICE guideline NG12) [9] [10] Whilst there is no evidence that Wegovy causes thyroid dysfunction in humans , you should report any new or unusual neck symptoms to your GP immediately
doi: 10.1186/s12944-016-0289-1 142 LuHSuSAjuwonKM
Importantly, headaches also occurred in placebo groups, which complicates the attribution of causality
