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Combination therapies Combination therapy with SGLT2 inhibitors and GLP-1 receptor agonists offers a promising approach to enhance cardiovascular and kidney protection in people with type 2 diabetes mellitus, particularly those at high risk [9,20]
A large meta-analysis of 45 RCTs recently found that compared with placebo or other interventions, GLP-1RAs did not increase the risk of thyroid cancer, hyperthyroidism, hypothyroidism, thyroiditis, thyroid mass, and goiter [69]
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Patients taking statins who develop new muscle symptoms while on GLP-1 therapy should contact their prescriber promptly, as this combination may increase the risk of muscle-related adverse effects in some individuals
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