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Many are comparing copper-peptide signaling against other remodeling agents already in their pipeline, choosing a spray format because it simplifies blinding and dose standardization across a treatment group
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This paradigm has inspired the conjugation of antibodies with PROTACs to generate degradable antibody conjugates (DACs), an approach aimed at overcoming the poor pharmacokinetics and insufficient tumor penetration that often limit the therapeutic window of small-molecule PROTACs
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