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PD mutations have not been shown to drastically alter the toxicity of -synuclein oligomers or fibrils, although more recent studies have indicated that the most potent toxic species responsible for PD are oligomers that are formed early on in the disease process [21]

Disulfide bonds in ER protein folding and homeostasis

Neurogenic orthostatic hypotension is a neurodegenerative form of dysautonomia in which the autonomic system loses the ability to properly regulate blood pressure as one moves from sitting or lying down to standing

Clinically, seizures have been observed in patients with brain lymphoma who underwent a brief BBB opening regimen (76)

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Polyamines in Protein Modification The butylamino group of spermidine is used in a posttranslational modification reaction important to the process of translation