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The limited available human clinical evidence evaluating BPC-157 and related peptide therapies in musculoskeletal settings is summarized in Table 2

No finalized large-scale human clinical trials are published that demonstrate safety and efficacy in humans

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Although the overall number (frequency) of Tregs may be unchanged in MS patients compared to controls, studies indicate that their inhibitory function is impaired, which correlates with diminished immune control in vivo ( Further studies have shown the absence of GSH in T cells does not interfere with TCR signaling but leads to a failure to reprogram cellular processes needed for robust clonal expansion and prevents the induction of aerobic glycolysis and the increase in cell size associated with T cell activation (Klein Geltink et al., 2017)

However, research on GHK-Cu gene expression actually shows anti-cancer effects, creating conflicting theoretical concerns