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Constipation can be especially bothersome, and for some people, it may become severe if not managed properly
But remember the human data: first-trimester GLP-1 exposure has not shown elevated birth defect rates in the observational studies conducted so far
Semaglutide is also available in oral form (Rybelsus), though oral bioavailability is significantly lower and the dosing schedule differs entirely from injectable formulations
Any potential immunomodulatory effects require rigorous investigation through properly designed clinical trials before therapeutic recommendations can be made
Bibcode:1983PhyRv..63.1420B
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