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65 Does the paradox that either GIPR agonist or antagonist exhibits benefits in combination with GLP-1R agonist correlates with the likely reduction of internalization, following the decrement of -arrestin recruitment or the acceleration of the dissociation rate (K off ) between the ligand and receptor, owing to competition between used agonists and antagonists in endogenous GIP
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doi: 10.3390/nu12020476 192 PykeCHellerRSKirkRKrskovCReedtz-RungeSKaastrupPet al
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