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this should be considered by clinicians in any trial or supervised setting, in line with NICE guideline NG28 (Type 2 diabetes in adults)
In clinical trials, participants taking semaglutide experienced weight loss plateaus around 60 weeks after starting the medication
For others, particularly those whose reward system is more broadly engaged through food, social interaction or creative work, the flattening extends into mood, drive and libido
Resveratrol gets more antioxidant genes expressed (superoxide dismutase, catalase, glutathione peroxidase) and thus encourages more activation of the Nrf2/ARE pathway
The smart approach is to eat structured meals even when appetite is minimal
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