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You might experience mild soreness at the injection site, but this usually fades quickly
ADA Standards of Care - Diabetes Care Journal : American Diabetes Association guidelines on GLP-1 receptor agonist dosing and management, including semaglutide titration recommendations
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The most significant published evidence to date comes from a phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023, which evaluated retatrutide across multiple doses in adults with obesity
Its half maximal inhibitory concentration (IC50) for GIPR is 42.4 nM, and its EC50 for GLP-1R is 24.4 pM in a human cell-based functional assays (74)
M.KleinR.et al (1996)
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