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Although the adjusted mean difference in weight reduction between treatments at 6 months was moderate in absolute terms, categorical outcomes reflect its strong clinical importance: for example, approximately twice as many tirzepatide-treated patients achieved 15% weight reduction compared with semaglutide-treated patients (31% vs

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Retatrutide is an investigational triple hormone receptor agonist targeting GIP, GLP-1, and glucagon receptors currently under clinical development for the management of obesity and type 2 diabetes

This approach is commonly used in medical practice, particularly for patients who require stronger metabolic support beyond a single medication