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The primary underlying pathomechanism is most likely a decreased hepatic GHR expression related to insulin deficiency, resulting in GH-resistance and impaired hepatic IGF-1 synthesis, which stimulates pituitary GH-secretion by a feedback mechanism [188, 189]

Retatrutide is an investigational drug not yet approved by the FDA

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Reduces the appearance of dark spots and uneven skin tones

Graphical abstract Access this article Similar content being viewed by others Data availability No new data were generated or analyzed in this study

Cycle length: Typically 4 to 8 weeks depending on indication and clinical response