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798,799 Intravenous injection of histochrome significantly reduces cardiac fibrosis, increases capillary density, and significantly improves cardiac function in I/R rats by upregulating the expression of Nrf2 and its downstream genes, including GPX4, and reducing intracellular and mitochondrial ROS levels

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10.1136/ard.2005.051078 10 ForresterS

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This is where the importance of a tightly regulated balance between ROS production and antioxidant defenses becomes evident

To confirm production and stability of these proteins in planta , a 3xFLAG tag was added to the N-terminus of CzNIS1a and CzNIS1a (No SP) and expressed in planta using the pICH86988 vector system