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Blood was collected via a jugular vein catheter at 5, 15 and 30 min and 1, 2, 4, 8 and 24 h after intravenous dosing, or for intraduodenal groups at 15 min predose and 0.5, 1, 2, 4, 8, 24 and 48 h postdose

Research Summary The preclinical foundation for retatrutide was established by Coskun et al

Side effects cluster in the first 72 hours after each weekly injection and in the first 2 to 4 weeks of every dose escalation