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Methods Enzymol 252:3853
The effect of ageing and osteoarthritis on the mechanical properties of cartilage and bone in the human knee joint
Visible changes in brightness and evenness of skin tone may take several weeks to months, depending on baseline pigmentation, dose, route of administration, and adherence to sun protection. Results are often subtle and natural-looking, and ongoing maintenance may be required to sustain benefits, especially in individuals with high sun exposure
Meanwhile, cytokines act as mediators of neutrophils and monocytes recruitment and amplify the inflammatory process by activating the release of various inflammatory mediators from the infiltrating leukocytes