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Landmon CA, Davies C, Pape SM, Bassett SE, McCann JD

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Although SS is classically considered to express the epithelial markers cytokeratin (CK) and epithelial membrane antigen (EMA), whereas MPNSTs classically express the neural markers S-100 protein and CD57, a significant percentage of cases show immunophenotypic overlap such that a subgroup of MPNSTs express EMA and CK and a proportion of SSs express S-100 and CD57 (20, 21, 22, 23, 24, 25, 26, 27)

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Precautions for Wegovy Risk of Thyroid C-Cell Tumors In mice and rats, semaglutide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) after lifetime exposure at clinically relevant plasma exposures [see Nonclinical Toxicology (13.1)]

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