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Carboplatin : Though less ototoxic than cisplatin, carboplatin also affects cochlear hair cells and can cause SHL, particularly at high doses or when used in combination with other chemotherapeutic agents (Funt et al

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Upon binding, it may influence signaling pathways associated with: Growth hormone release patterns Endocrine system regulation Peptide stability and circulation time The DAC modification is specifically examined for its potential to extend peptide activity by binding to plasma proteins, thereby allowing prolonged exposure in experimental models

The post also notes both classes carry similar side effect profiles, so the difference lies in pathway coverage rather than in tolerability

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