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Importantly, this region contributes much less to receptor binding than to binding-protein binding, which is what makes the modification useful: it separates the two interactions rather than weakening both

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This triggers: Enhanced insulin secretion in response to meals, lowering blood glucose

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Many patients achieve meaningful weight loss with semaglutide, but research has shown that tirzepatide generally results in larger average reductions in body weight, particularly at higher maintenance doses

And, at some point, you have to wonder how much of this stuff is actually made up