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Physiol Behav 283: 114622

While animal studies extending to 6 weeks have found no concerning signals, humans using the peptide are essentially participating in uncontrolled self-experimentation regarding long-term outcomes

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Any stomach disorders, or conditions like pernicious anemia where Intrinsic Factor is lacking, can prevent B12 absorption, as can intestinal inflammation such as Crohns disease if a damaged terminal ileum cannot take up vitamin B12

Also of note, too much copper intake can make you nauseous and give you gastrointestinal issues