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Intestinal barrier dysfunction, LPS translocation, and disease development

Cellular GSSG accumulation, as opposed to GSH reduction, rendered hepatocytes susceptible to TNF cytotoxicity Increased GSSG/GSG ratios in response to H 2 O 2 exposure can stem from both GSH reduction and GSSG accumulation (data not shown)

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Loui A, Raab A, Maier RF, Bratter P, Obladen M

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