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Beyond the demonstration that pharmacologic blockade of IGF-1R signaling can favorably impact lifespan, these data also provide new insights into temporal and metabolic aspects regarding this pathway and aging

Underlying liver and pancreas considerations still apply

The bigger concern is not a lack of effectiveness, but an increase in side effects like nausea and a higher risk of dangerously low blood sugar

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Plant Biol 16:5867 Liu W, An H-M, Yang M (2013) Overexpression of Rosa roxburghii l-galactono-1,4-lactone dehydrogenase in tobacco plant enhances ascorbate accumulation and abiotic stress tolerance