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Its high prevalence, especially in the elderly, and its negative impact on physical function make it a leading cause of disability in the elderly

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Neurotransmitters can be broadly divided into two main classes: small amino acids (e.g., aminobutyric acid [GABA], glutamate, aspartate, and glycine) and biogenic amines (e.g., dopamine, epinephrine, norepinephrine, serotonin, histamine, and acetylcholine) (11)