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Further increases to 1 mg or 2 mg may follow at four-week intervals

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Specifically, the activity and transcript abundance of glutathione peroxidases, which convert GSH to GSSG, increased in infested resistant plants, but the enzymatic activity and transcript abundance of glutathione reductases, which converts GSSG back to GSH, did not change

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Discontinuation rates due to GI side effects ranged from 4-7% across tirzepatide doses in these clinical trials

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