Neuronale Zeroidlipofuszinose 12 (NCL-12) - Australian Cattle Dog Mischling Dogs with two copies of

Dogs with two copies of mutation (homozygotes for mutation) are called „bully' Whippets

Thus the dog with a genotype b/b on B locus has all the pigmented areas changed from black to chocolate/liver brown (dog that is fawn/sable (Ay) is a livernose

Histopathologische Untersuchungen zeigen eine Spaltung der Epidermis von der darunterliegenden Dermis innerhalb oder direkt unterhalb der Basalmembran

Eine Mutation in diesem Gen ist verantwortlich für das Auftreten einer demyelinisierenden peripheren Neuropathie mit abnormal gefaltetem Myelin

Acepromazine

Neuronale Zeroidlipofuszinose 12 (NCL-12) - Australian Cattle Dog Mischling Dogs with two copies ofNeuronal ceroid lipofuscinosis is a lysosomal storage disease, characterized by neurodegeneration and decline in neurological functions at approximately 6 years of age due to accumulation of autofluorescent lysosomal storage bodies in cells of the central nervous system, as well as many other tissues. The clinical signs also include anxiety, impaired ability to recognize and respond to previously learned commands, increased sensitivity to loud or