Neuronale Zeroidlipofuszinose 8 (NCL-8) - Alpenländische Dachsbracke Diversität The majority of puppies affected

The majority of puppies affected with NCCD are euthanized shortly after diagnosing the first signs of this disease

Affected dogs have abnormal platelet function because they are not able to stick together properly and therefore cannot form a clot

D-Locus is not responsible only for coat pigment dilution but also dilutes pigment of the nose

Mutation: CCDC39 gene

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Neuronale Zeroidlipofuszinose 8 (NCL-8) - Alpenländische Dachsbracke Diversität The majority of puppies affectedNeuronal ceroid lipofuscinoses (NCLs) are a group of heritable diseases characterized by progressive neuronal degeneration and the accumulation of autofluorescent cytoplasmic inclusions in the brain, retina and other tissues. Clinical symptoms and progress of the disease include increased rates of irritability, with the possibility of outbursts of aggression, hallucinations, hyperactivity and seizures. Most animals lose their ability to coordinate