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Mutation: SCARF2-Gen
which would result in restrictions on the breeding of affected dogs
the defects in collagen lead to fragility
Mutation: NECAP1 gene
In most instances
Schwere kombinierte Immundefizienz, x-chromosomal (X-SCID) Diversität Mutation: SCARF2-GenX linked severe combined immunodeficiency is a rare immune disorder. The main symptoms are lymphopenia, absence of palpable peripheral lymph nodes, small thymic size and T cells that are unresponsive to proliferative stimulation due to low or absent IgG and IgA antibodies. Other signs include diarrhoea and vomiting. The affected puppies are exposed to chronic recurrent infections which are lethal in the combination with immunodeficiency. Male puppies
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