Osteogenesis Imperfecta (OI) - Beagle Startseite that affect foetal development

that affect foetal development

mm = non merle

giving an overall comma-like morphology to the body

The condition is progressive

Affected dogs experience unpredictable seizures with increased aggression

Osteogenesis Imperfecta (OI) - Beagle Startseite that affect foetal developmentOsteogenesis imperfecta is an autosomal dominant disease caused by a mutation in the COLA2 gene, which encodes collagen. Mutations altering the sequence can lead to disruptions of the collagen structure, which can lead to abnormally brittle bones that fracture very easily. The disease can be found in several dog breeds. The affected newborn puppies are exposed to fractures affecting almost every long bone right after birth and often have to be