D-Lokus (d3) CatCheck high sensitivity to light

high sensitivity to light

CDDY/IVDD was associated with FGF4 gene insertion on chromosome 12

severe mental retardation

Betroffene Hunde zeigen klinische Anzeichen von Kehlkopflähmung oder Megaösophagus

because E allele is dominant eumelanin production is normal and expression of other loci can determine coat colour

D-Lokus (d3) CatCheck high sensitivity to lightD Locus is responsible for coat colour dilution. Known mutations of the MLPH gene (melanophilin) are responsible for most cases of diluted colours. MLPH gene encodes a protein melanophilin, a key component in the hair and skin pigment formation. A mutation in the gene causes the improper distribution of melanosomes and coat colour dilution. It has an effect on the formation of black eumelanin as well as red yellow pheomelanin, though in lesser extent.