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Chondrodysplasia (CDPA) is defined as an inherited condition characterized by abnormal growth at the ends of bones
was zu einer Verschlechterung der Innenohrhaare und Taubheit führt
tremor in the trunk of the body
In Australian Shepherds the disease was identified between 4 and 19 months of age
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E-Lokus DogCheck Chondrodysplasia (CDPA) is defined asMelanocortin 1 receptor (MC1R) on E Locus is responsible for regulation of pigment production in melanocytes. Mutation inMC1R gene results in non functional receptor and switches pigment production to pheomelanin. Because production of eumelanin is disabled, effect of other loci is not possible. Mutation is recessive therefore, two such alleles are necessary for yellow red (pheomelanin) coat colour expression. Different dog breeds with genotype e e
