Kongenitale Ichthyose - Deutsche Dogge Searchterm Severity of clinical signs vary

Severity of clinical signs vary

for breeding approval or club registration)

Mutation: AP3B1 gene

characterized by severe footpad hyperkeratosis

I-Locus causes so called »extreme dilution« of the pheomelanin

Kongenitale Ichthyose - Deutsche Dogge Searchterm Severity of clinical signs varyHereditary ichthyoses represent a heterogeneous group of skin cornification disorders characterized by hyperkeratosis and blistering or scaling of different severity levels. In Great Dane the disease is characterized by severe hyperkeratosis with a formation of strongly wrinkled, thickening and scaling skin, especially in the region of eyes and nose. The symptoms become evident right after birth and thus include dry and scaling skin, untidy appearance